Institute of Clinical Epidemiology


Quality Epidemiological Research for Better Health of the Filipino People


The Institute of Clinical Epidemiology (ICE) is one of the components of the National Institutes of Health-University of the Philippines Manila.  The creation of the Institute was approved during the 1107th meeting of the Board of Regents on 17 April 1997.  The primary role of the Institute is to conduct rigorous relevant researches for the improvement of health care using the principles of clinical epidemiology and its related disciplines and to provide technical services in support of research development. The secondary role of the Institute is to advocate for and assist in the teaching of graduate and undergraduate programs in Clinical Epidemiology in the Department of Clinical Epidemiology, UP College of Medicine. Thus, the Institute Director is also the Chair of the Department and the faculty of the department are affiliate faculty of the institute.

The Clinical Epidemiology Unit of the UP College of Medicine, the predecessor of ICE, pioneered the discipline of clinical epidemiology in the country.  Through the years, ICE has established itself as a leader in the conduct of rigorous epidemiologic researches that served as basis for evidence based health policies and clinical practice guidelines aimed at improving the quality of health care for the Filipino people.

The Institute is recognized for its expertise is in the conduct of health systems and policy research, program monitoring and evaluation, implementation researches that provide guidance on the direction of health programs and policies in the country.  The Institute and the Department pioneered the teaching and practice of evidence-based medicine through training workshops across the country.  Through the leadership of Dr Ernesto Domingo and Dr Mary Ann Lansang, the discipline of clinical epidemiology was propagated and the discipline has evolved as a dynamic and relevant resource in the research environment. The Institute and the Department continues to train a critical mass of clinical epidemiologists through its Diploma and Master program and provides capacity building research-related workshops adapted to the needs of various health care providers.  Its faculty has been in the forefront of issues of public health importance, advocating for rigorous and ethical conduct of researches, independent critical appraisal of evidence towards the formulation of evidence-based recommendations and health policies.


A trans-disciplinary institute of excellence in the conduct and utilization of relevant, quality researches using the principles of clinical epidemiology and its related disciplines towards equitable, efficient and culturally appropriate health care for the Philippines and Southeast Asia Region.


Guided by the principles of scientific rigor, integrity and ethics, we commit to provide expertise, capacity building, and nurture leadership in the design and conduct of essential researches in health care, translation of research into health policies utilizing the principles of clinical epidemiology and its related disciplines for improved health care and equity.


Integrity Collaboration Excellence & Equity

CORE Function

The Institute shall perform the following functions distinct from the Department of Clinical Epidemiology

  • Conduct epidemiology researches for the improvement of health care and aligned to the national health research agenda
  • Undertake systematic reviews, policy evaluation and other integrative studies on critical health related issues
  • Provide technical services in the evaluation of research proposals, conduct of research and policy development
  • Initiate health research-related capacity building training workshops
  • Disseminate results of research undertaken in the institute


The Institute aims to:

  • Generate relevant health research addressing the priority health care needs of the Filipino people
  • Optimize the translation of research results in decision-making at the individual and program levels
  • Provide technical assistance in the evaluation of health care needs in the country, identification of effective and efficient health interventions, rational allocation of resources and implementation and monitoring of programs
  • Train health providers on the application of quantitative and qualitative assessment principles drawn from clinical epidemiology, health economics, biostatistics, and health social science
  • Provide continuing education on advances in health research methods

Specifically, the Institute shall perform the following functions:

  1. Conduct research on clinical practice and population-based medicine for the improvement of health care
  2. Develop novel research methodology or adapt existing methodologies to fit available resources and the cultural context of a developing country
  3. Conduct systematic reviews and policy evaluations on critical issues facing health care providers
  4. Do relevant policy research and liaise with legislative and executive officials and other major stakeholders in health
  5. Conduct workshops and short courses on clinical epidemiology and policy development
  6. Assist in the teaching and administration of the MS Epidemiology (Clinical Epidemiology) course
  7. Provide technical and extension services in research and policy development as needed to the Department of Health, Philippine Health Insurance Commission, College of Medicine, professional societies and other organizations with research or policy needs
  8. Disseminate and publish results of researches

Training Workshops:

To fulfill its mission, ICE, in partnership with the Department of Clinical Epidemiology, offers the following workshops to increase awareness of research and to equip health practitioners with the skills and knowledge necessary to become critical users and doers of research.

  1. Research Methodology
  2. Evidence-based Medicine
  3. Development of Systematic Reviews and Clinical Practice Guidelines
  4. Good Clinical Practice and Ethics
  5. A Mixed Methods Approach to Health Research
  6. Data Management and Statistics for Health Research
  7. Effective Writing and Presentation of Scientific Researches
  8. Training for Technical Review Board Members

ICE participates in the training of students of the Master of Science in Clinical Epidemiology and Diploma in Clinical Epidemiology Programs, which are offered through its academic partner, the Department of Clinical Epidemiology.  ICE also accommodates students from Philippine Science High school for their Science Internship Program and undergraduate statisticians from the University of the Philippines Los Banos for their on-the-job training requirements, among others. ICE in collaboration with DCE also designs training programs for its local partners such as the Health Policy Internship Program for the health policy interns and fellows of the Department of Health in 2015.

Research Programs

The Institute undertakes the necessary key researches in clinical practice and population-based medicine for the improvement of the quality of health services in both public and private sectors. 

Study Groups/Areas and Ongoing/Completed Researches

  1. ASTRO (Advanced Study and Research in Orthopedics) Study Group
    • Quality of life of patients with traumatic brachial plexus injuries
    • Nerve transfers for shoulder reconstruction in brachial plexus injuries
  2. LIFE course study in CARdiovascular disease Epidemiology (LiFECare)
    • The Healthy Health Workers Study: "Health profile and understanding of cardiovascular risk among community workers in selected areas in the Philippines"
  3. Environmental Health
    • Indoor Air Quality, Airborne Infection and Ventilation: Exposure assessment of hospital pay and charity wards of the Philippine General Hospital
    • Heavy metals, black carbon, inflammation, blood pressure and lung function: exposure assessment of traffic enforcers of the Metropolitan Manila Development Authority
  4. Schistosomiasis and other Neglected Tropical Diseases
    • Focal Prevalence Survey of Schistosomiasis in Endemic Areas
    • Integrated school-based control of selected neglected tropical diseases in Davao del Norte: Impact evaluation
  5. Tuberculosis
    • The 2016 National TB Prevalence Survey
    • Missing TB cases seen in the 2016 National TB Prevalence Survey: A qualitative study
    • Rapid situational analysis of MDR TB
    • TB and DM Control and Care: A rapid situational analysis for planning a coordinated program response
  6. HIV
    • HIV Gaming, Engaging and Testing (HIV GET)
    • Immune Activation Dynamics of Filipino HIV Patients on Antiretroviral Therapy
  7. Health Systems Research
    • Protection of Children on Abuse and Exploitation Online: Capacity Gap Analysis of Stakeholders
    • Philippine Health Information System on Mental Health Conditions
  8. Clinical Epidemiology Researches
    • Symptom Prevalence Bother and Treatment Satisfaction in Men with Lower Urinary Tract Symptoms in Southeast Asia: A Multinational, Cross-Sectional Survey
    • Determining the epidemiology of surgical site infections after gastrointestinal surgery: A pilot practice audit research in the Department of Surgery - Philippine General Hospital and a global collaborative clinical audit (GlobalSurg2)
  9. Economic evaluations
  10. Clinical practice guideline development


  • Department of Health
  • Department of Science and Technology
  • Philippine Council for Health Research and Development
  • Philippine Institute of Developmental Studies
  • World Health Organization
  • International Clinical Epidemiology Network
  • UP- School of Economics
  • Philippine Coalition Against Tuberculosis
  • National Kidney and Transplant Institute
  • Philippine College of Chest Physicians
  • Philippine Society of Diabetes, Endocrinology and Metabolism


Marissa M. Alejandria, MD, MSc, FPCP, FPSMID
Professor 12
Clinical Epidemiologist - Infectious Diseases

Deputy Director

Emmanuel P. Estrella, MD, MSc, FPOA
Research Associate Professor 7
Clinical Epidemiologist- Orthopedic Surgeon


Research Faculty

  1. Emmanuel S. Baja, ScD
    Research Professor 2  
  1. Mary Ann J. Ladia, PhD
    Research Associate Professor I
    Medical Anthropologist
  1. Marie Carmela M. Lapitan, MD, MS Clinical Medicine
    Research Professor 12
  1. Olivia T. Sison, MSPH
    Research Assistant Professor 6


Affiliate Faculty from the Department of Clinical Epidemiology

       Jacinto Blas V. Mantaring, MD, MSc
       Professor 12
       Clinical Epidemiologist and Neonatologist

       Nina T. Castillo-Carandang, MA, MSc, PhD
       Professor 5
       Health Social Scientist

       Cynthia P. Cordero, MSc, MMedStat
       Professor 12

       Maria Lourdes E. Amarillo, MPH (Biostatistics)
       Professor  2

       Noel R. Juban, MD, MSc
       Professor 10
       Clinical Epidemiologist and Community Medicine Specialist

       Carlo Irwin A. Panelo, MD, MA
       Professor 1
       Clinical Economist

Project Development Officer

Lailanie Ann C. Tejuco, LPT

Contact Information

Telefax : (632) 8 525-4098
E-mail address:
Address : Institute of Clinical Epidemiology
Room 201, National Institutes of Health University of the Philippines Manila
Pedro Gil St., Ermita, Manila