Institute of Clinical Epidemiology

As approved by the UP BOR on 17 April 1997, the Institute primarily conducts relevant research for the improvement of health care using the principles of clinical epidemiology and its related disciplines and to provide technical services in support of research development. The Institute promotes expertise and conduct of essential research in health care and formulation and adoption of health policies emanating from these researches.

ICE has established itself as a leader in conducting clinical epidemiologic research that served as the basis for health policies and clinical practice guidelines. The Institute is recognized for its expertise in doing health systems and policy research, program monitoring and evaluation, and implementation research that provide guidance on the direction of health programs and policies in the country. Its faculty has been in the forefront of issues of public health importance, advocating for rigorous and ethical conduct of research, independent critical appraisal of evidence towards the formulation of evidence-based recommendations and health policies. ICE also established its role as a reliable resource for technical assistance in clinical research, health policy and systems research, environmental and occupational health research, statistical analysis, database design, and data management. 


ICE, in partnership with the Department of Clinical Epidemiology, offers the following workshops to increase awareness of research and to equip health professionals with the skills and knowledge necessary to become critical users and doers of research: 

  1. Research Methodology

  2. Evidence-based Medicine

  3. Development of Systematic Reviews

  4. Development of Clinical Practice Guidelines

  5. Good Clinical Practice and Ethics

  6. A Mixed Methods Approach to Health Research

  7. Data Management and Statistics for Health Research

  8. Effective Writing and Presentation of Scientific Research

  9. Training for Technical Review Board Members


Marissa M. Alejandria, MD, MSc

Professor of Infectious Disease and Clinical Epidemiology


Emmanuel S. Baja, DSc

Research Professor of Environmental Health and Epidemiology

  1. Clinical and Socio-Demographic Characteristics, and Service Utilization of Transgender Men and Women in a Community-Based Setting: A Cohort Profile from 2017 to 2019 – Principal Investigator 

  2. Assessing the Effect of COVID 19 Pandemic, Shift to Online Learning, and Social Media Use on Mental Health Among College Students in the Philippines: A Mixed-Method Study – Principal Investigator

  3. Exposure Assessment of Person Living with HIV on Electronic and Conventional Cigarette Usage, Stress and Respiratory Health: A single center mixed-methods study – Principal Investigator

  4. Association between consumption of fermented rice wine (Tapuy) and less with Alzheimer’s disease and early signs of dementia – Principal Investigator

  5. Acceptability and Feasibility of HIV Self-Screening (HSS) among Men-Having-Sex with Men (MSM) and Transgender Women (TGW) in Metropolitan Manila, Philippines: A Demonstration Study – Principal Investigator

  6. Risk Factors, Clinical Characteristics and Transmission of Covid 19 in Non-Pregnant and Pregnant Women in the Philippines: A multicenter study – Co-Investigator

  7. Water-based Epidemiology for SARS-CoV-2 Genetic Analysis and Surveillance in Mindanao (WAGAS Mindanao): Proof-of-Concept – Co-Investigator

  8. RabCast: Proof-of-concept for a Forecasting Tool for Rabies Spread in Davao City Through Combined Genomic and Mathematical Approaches - Co-Investigator

  9. Integrated Wastewater-Based Epidemiology and Data Analytics for Community-Level Pathogen Surveillance and Genetic Tracking: Proof-of-Concept - Co-Investigator

Emmanuel P. Estrella, MD, MSc

Research Associate Professor of Orthopaedics & Clinical Epidemiology


Mary Ann J. Ladia, PhD

Research Associate Professor of Medical Anthropology


  1. Rapid review of COVID-19 mobile health technologies in the workplace – Co- Investigator

Marie Carmela M. Lapitan, MD, MSc

Research Professor of Urology & Clinical Epidemiology

  1. Rapid review of the evidence on prioritized COVID-19 technologies and interventions Principal Investigator

  2. Rapid review of COVID-19 mobile health technologies in the workplace – Principal Investigator

  3. Elective Operating Room Quality and Efficiency of Surgical Services Delivery in a Tertiary Government Training Hospital in the Philippines During the COVID-19 Pandemic Principal Investigator              

  4. A Cluster Randomised Feasibility Study of a Sustainable Nutritional Intervention for Patients Undergoing Cancer Surgery in Low- and Middle-Income Countries (LMIC) - Country Lead/Principal Investigator

  5. Malnutrition and nutritional screening in patients undergoing surgery in low and middle income countries: a systematic review - Co-Investigator

  6. EAU Guidelines on the management of female non-neurogenic lower urinary tract symptoms - Co-Investigator

  7. Botulinum toxin for treating idiopathic overactive bladder in men: a systematic review - Co-Investigator

  8. Outcomes on Enhanced Recovery After Surgery (ERAS) Protocol Versus Standard Care after Radical Cystectomy in UP-PGH - Co-Investigator

Olivia T. Sison, MSPH, ScM

Research Assistant Professor of Public Health & Epidemiology



Institute/Center administration:

Director: Marissa M. Alejandria, MD, MSc, FPCP, FPSMID

Assistant Director: Emmanuel P. Estrella, MD, MSc, FPOA

Office Address: Room 201, National Institutes of Health Building, UP Manila