Institute of Clinical Epidemiology (ICE) Director

Marissa M. Alejandria, MD, MSc, FPCP, FPSMID

Director, Institute of Clinical Epidemiology (ICE)

Other Positions Held: 

    Chair, Department of Clinical Epidemiology, UP College of Medicine 2013 - present
    Professor, Department of Clinical Epidemiology, UP- College of Medicine
    Clinical Associate Professor, Infectious Diseases Section, Dept of Medicine, UP-PGH
    Training Officer, Section of Infectious Diseases, Department of Medicine, Philippine General Hospital
    Consultant, Section of Infectious Diseases, Department of Medicine, The Medical City
    Member, Institutional Review Board, The Medical City
    Chair, Committee on Publications, Philippine Society for Microbiology and Infectious Diseases
    Treasurer and Board Member, Philippine Society for Microbiology and Infectious Diseases
    Secretary, Foundation for the Control of Infectious Diseases, Inc
    Editorial Board Member , Journal of the ASEAN Federation of Endocrine Societies
    Section Editor (Hospital Epidemiology), International Journal of Critical Illness and Injury Science

Degrees: 
    College
    1978-82, B.S. Public Health , University of the Philippines College of Public Health, cum laude
    1982-86 Doctor of Medicine, University of the Philippines College of Medicine

    Postgraduate Training
    1986-87 Post graduate Internship UP-Philippine General Hospital
    1988-89 M.Sc. Clinical Tropical Medicine, Mahidol University, Bangkok, Thailand
    1995-97 Residency Training in Internal Medicine, UP-Philippine General Hospital
    1998-99 Clinical Fellowship in Infectious Diseases UP-Philippine General Hospital
    1999-2005 M.Sc. Clinical Epidemiology, UP-College of Medicine

    Other Training
    Arthur Ashe Fellow, International Health Care Worker Observation in Clinical Management of HIV Disease at New York Presbyterian Hospital-Weill Cornell Medical Center, October 6-31, 2013
    Intensive Update Course in Clinical Tropical Medicine and Travelers’ Health, Toronto, Ontario, Canada, October 10-11, 2006
    WHO-TDR Training Course for Potential TDR Clinical Trial Auditors, Manila, Philippines, December 11-13, 2006
    WHO-TDR Refresher Course on Good Clinical Practices for TDR Clinical Monitors, Hua Hin, Thailand, August 16-18, 2006
    WHO-TDR Training Workshop on Good Clinical Practice for Potential Clinical Monitors, Bangkok, Thailand, August 22-27, 2005
    Tim Albert Short Course Training for Medical Journal Editors, BMJ Publishing Group, September – October 2002
    Infectious Diseases Exchange Fellowship Program between Mayo Clinic, Rochester, Minnesota, USA and UP-College of Medicine, Sept 2000 – Nov 2000

    Awards
    Recipient, Philippine College of Physicians Exemplar Award for Clinical Research, May 2012
    Recipient, UP Manila Research Productivity Gawad Chancellor Award, October 31, 2011
    Outstanding Alumni for Health and Allied Service, Siena College Quezon City, February 2011
    Presidential Award from the Philippine Society for Microbiology and Infectious Diseases, 2004, 2007 and 2010 for work done as Committee Chair on Research and Development
    Kenneth Warren Prize Awardee for best review published in the Cochrane Database of Systematic Reviews (Intravenous immunoglobulin for treating sepsis and septic shock), given at the 8th International Cochrane Colloquium, Cape Town, South Africa, 2000
    Ramon Abarquez Awardee for Most Outstanding Fellow for 1999, Department of Medicine, UP-PGH
    Clemente Gatmaitan Awardee for Most Outstanding Researcher for 1999, Department of Medicine, UP-PGH
    Most Outstanding Graduate, B.S. Public Health, UP- College of Public Health, 1982

Recent Publications: 

International

Liu Q, Abba K, Alejandria MM, Sinclair D, Balanag VM, Lansang MAD. Reminder systems to improve patient adherence to tuberculosis clinic appointments for diagnosis and treatment. Cochrane Database of Systematic Reviews 2014, Issue 11. Art. No.: CD006594. DOI: 10.1002/14651858.CD006594.pub3.

Hilton Y. Lam, MHA, PhD; Vicente Y. Belizario, MD, MTM&H; Noel R. Juban, MD, MS; Marissa M. Alejandria, MD, MS; Nina Castillo-Carandang, MA, MS; Elizabeth Arcellana-Nuqui, MD; Ma. Angelina Mirasol, MD; Cynthia P. Cordero, MSPH, MMedStat; Olivia T. Sison, MSPH; and Adovich S. Rivera. Assessing the Residual Risk for Transfusion- Transmitted Infections in the Philippine Blood Supply.  YALE JOURNAL OF BIOLOGY AND MEDICINE 2014; 87:299-306.

Alejandria MM, Lansang MA, Dans LF, Mantaring JBV.  Intravenous  immunoglobulin for treating sepsis and septic shock.  The Cochrane Database of Systematic Reviews 2013 Sep 16; 9: PMID: 24043371 

Mendoza MT, Roxas E, Ginete J, Alejandria MM, Roman AD, Leyritana KT, et al. Clinical Profile of Patients Diagnosed with Leptospirosis After a Typhoon. Southeast Asian Journal of Tropical Medicine and Public Health 2013; 44(6):1021-1035

Hseuh PR, Hoban DJ, Carmeli Y, Chen SY, Desikan S, Alejandria M, et al. Consensus review of the epidemiology and appropriate antimicrobial therapy of complicated urinary tract infections in Asia-Pacific region. Journal of Infection 2011; 63: 114-23

Quin L, Abba K, Alejandria MM, Lansang MA, Berba RP, Balanag V. Reminder systems and late patient tracers in the management of tuberculosis. The Cochrane Database of Systematic Reviews 2008, Issue 4

Alejandria MM, Lansang MA, Dans LF, Mantaring JBV.  Intravenous  immunoglobulin for treating sepsis and septic shock.  The Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD 001090. DOI:  10.1002/14651858

Ngeow YF, Suwanjutha S, Chantarojanasriri T, Wang F, Saniel M, Alejandria M et al.  An Asian study on the prevalence of atypical pathogens in community-acquired pneumonia.  Int J Infect Dis 2005; 9: 144-53

Alejandria M.  Effects of supportive treatments for dengue hemorrhagic fever or dengue shock syndrome in children.  BMJ Clinical Evidence 2006

Garner P, Alejandria M, Lansang MA (2006) Is DOTS-Plus a feasible and cost-effective strategy? PLoS Med 3(9): e350. DOI: 10.1371/journal.pmed.0030350

Camer GA, Alejandria M, Amor M, Satoh H, Muramatsu Y, Ueno H, Morita C. Detection of antibodies against spotted fever group Rickettsia (SFGR), typhus group Rickettsia (TGR) and Coxiella burnetii in human febrile patients in the Philippines. Jpn J Infect Dis. 2003 Feb;56(1):26-8.

Some Local Publications

Jalac S, de Vera M, Alejandria M. The use of colloids vs crystalloids in pediatric dengue shock syndrome: a systematic review and meta-analysis. Phil J Microbiol Infect Dis 2010; 39: 14-27 (Presented at the PSMID Research Forum and The Medical City Research Forum (Best Paper))

Alejandria MM. Amarillo MLE, Lansang MA. The accessibility and utilization of mobile phones among TB patients: a feasibility survey for short messaging service (SMS) as a strategy to improve adherence to Tb services. Acta Medica Philippina 2009; 43: 10-14  (Presented at the Philippine Coalition Against Tuberculosis Annual Convention, August 2007)

Chua MM, Alejandria MM.  The epidemiology of Acinetobacter infections among critically ill adult patients admitted at the UP-PGH. Phil J Microbiol Infect Dis 2008; 37: 38-53 (Presented at the Infectious Diseases Society of America (IDSA) Annual Meeting, Washington DC, 2008,)

Taguiang-Abu CU, Alejandria MM. Clinical determinants of outcomes of severe sepsis among adult patients at the Philippine General Hospital intensive care units. Phil J Int Med 2008; 46: 103-12 (Presented at the IDSA Annual Meeting, Toronto, Canada 2006; Best Paper, Dr Antonio Gonzaga Memorial Research Award, 2005)

Destura RV, Alejandria MM, Mendoza MT, Cajucom MA, Ang CF. The clinical utility of monoclonal antibody-based DOT-ELISA urine antigen detection in the diagnosis of leptospirosis. Phil J Int Med 2007; 45 (1): 1-6

Clinical Practice Guidelines for the Diagnosis, Treatment, Prevention and Control of Tuberculosis in Adult Filipinos: 2006 Update. Phil J Microbiol Infect Dis 2006; 35: 5-101

Alejandria MM, Jamias J, Ecarma R, et al. Validation of a risk assessment scoring system in adult patients with febrile neutropenia and malignancies.  Phil J Microbiol Infect Dis 2005; 34: 19-29 (Presented at the International Congress of  Chemotherapy, Manila, Philippines 2005)

Jamias JD, Mendoza MT, Alejandria MM, Baylon HG. The utility of stool surveillance cultures and clinical profile of febrile neutropenic patients at the National Kidney and Transplant Institute. Phil J Microbiol Infect Dis 2005; 34:71-78

Gutierrez AA, Alcantara CS, Alejandria MM. The incidence of Clostridium difficile-associated diarrhea at the adult intensive care units of the University of the Philippines-Philippine General Hospital. Phil J Microbiol Infect Dis 2005; 34: 79-85

Zoleta L, Alejandria MM, Berba RP.  Antimicrobial resistance patterns and clinical outcomes of health-care associated infections due to Enterobacteriaceae among critically ill patients.  Phil J Microbiol Infect Dis 2004; 33: (Presented at the Internationl Congress of Chemotherapy, Cancun, Mexico)

Salamat SS, Alejandria MM.  Salmonella Group C neck abscess in a diabetic patient.  Phil J Microbiol Infect: 2004; 33: 37-39

Dimatatac E, Alejandria MM, Delino R, Montalban C. Clinical and economic consequences of Pseudomonas aeruginosa resistant infections.  Phil J Microbiol Infect Dis 2003; 32: 159-67 (Presented at the  International Clinical Epidemiology Network Meeting, Egypt, 2002)

SARS Technical Working Group.  SARS Clinical Guidelines for Health Facilities in the Philippines.  Phil J Microbiol Infect Dis 2003; 32: 117-32

 

Chapters in books/Monographs

Philippine Practice Guidelines Group in Infectious Diseases. Clinical Practice Guidelines for the Empiric Management of Community Acquired Pneumonia 2010 Update

Philippine Clinical Practice Guidelines on the Diagnosis, Management and Prevention of Leptospirosis 2010

Philippine Guidelines on Immunization for Adults Living with HIV 2010

Alejandria M.  Dengue hemorrhagic fever or dengue shock syndrome in children.  Clinical Evidence BMJ Publishing Group Ltd 2009

Alejandria MM, Tumanan-Mendoza BA, Villaruz-Sulit MV, Dans AL. Evaluation of Systematic Reviews. In: Dans, AL, Dans LF, Silvestre MA, editors. Painless Evidence-Based Medicine. John Wiley& Sons, Ltd. England; 2008 p. 99-113

Alejandria MM, Berba RP, Balanag V et al. Screening and Immunization for Infectious Diseases.  In: Dans AL, Morales DD, editors.  Philippine guidelines on periodic health examination (PHEX).  University of the Philippines Manila: The Publications Program Information, Publication and Public Affairs Office; 2004. p.105-77

Task Force on Tuberculosis, Philippine Practice Guidelines Group in Infectious Diseases. Clinical Practice Guidelines for the Diagnosis, Treatment, Prevention and Control of Tuberculosis in Adult Filipinos: 2006 Update. Vol 2, No 3 Copyright 2006

Task Force on UTI 2003-04, Philippine Practice Guidelines Group in Infectious Diseases.  Urinary Tract Infections in Adults: Clinical Practice Guidelines Update 2004.  PPGG-ID Philippine Society for Microbiology and Infectious Diseases Vol2, No 1 Quezon City, Philippines. Copyright PSMID 2004

Monograph on Interim Clinical Guidelines on Severe Acute Respiratory Syndrome (SARS) for Health Facilities in the Philippines. Abridged Version July 25, 2003 Department of Health Technical Working Group on SARS      

 

Recently Completed Researches/ Projects

Health Policy Capability Building Program for Health Policy Associates and Interns of the Department of Health – August 2013 to Dec 2014

Philippine Clinical Practice Guidelines on Urinary tract infections 2013 Update – completed 2014 under the Philippine Society for Microbiology and Infectious Diseases as Co-Chair of the Task Force

Tuberculosis and Diabetes Mellitus Control and Care: A Rapid Situational Analysis for Planning a Coordinated Program Response – completed 2014 for the Department of Health through the Philippine Institute of Developmental Studies

Rapid assessment of the extent and quality of participation of private health facilities in the implementation of TB DOTS in the Philippines – completed 2014 as principal investigator

Prevalence and risk factors for TMP-SMX resistant E.coli among women with uncomplicated UTI – Accepted for poster presentation 52nd ICAAC Chicago, USA Sept 2012

Henson KR, Gamponia KS, Alejandria MM, Destura RV, Saniel MC. Prevalence and risk factors for extended-spectrum beta-lactamase-producing organisms among patients with complicated urinary tract infections in a developing country. Poster session presented at: 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC); 2013 September 10-13; Denver, CO, USA.

Prevalence and risk factors for ESBL resistant pathogens among patients with complicated UTI at the Philippine General Hospital – Accepted for poster presentation, IDSA San Francisco, California Oct 2013

The evolving epidemiology of people living with HIV in a developing country in the midst of an epidemic: a descriptive cohort, Accepted for Poster Presentation, IDSA San Francisco, California Oct 2013

A Comparison of the Clinical Utility of Three Rapid Serologic Tests in the Diagnosis of Typhoid Fever among Admitted Patients at the Philippine General Hospital

Consultant, Evaluation of Dengue Disease Management Software for the Philippine Council for Health Research and Development, Nov 2011 to Jan 2012

Co-investigator, Efficacy and safety of adjuvanted influenza vaccine, 2010-2011

Co- investigator, Cost of Treatment and Outcomes of Leptospirosis Using Penicillin G and Ceftriaxone: A Comparative Observational Study 2010, Accepted for Poster Presentation WPCCID, Singapore, 2011

Co-investigator, Clinical Utility of Modified Faine’s Criteria for the Diagnosis of  Leptospirosis 2010, Accepted for Poster Presentation, ICC, South Korea, 2012

Co-investigator, Leptospirosis Outbreak After a Heavy Rainfall Typhoon in the Philippines: Clinical Features, Risk Factors for Mortality and Outcomes 2010, Accepted for Poster Presentation, IDSA, 2010; Accepted for Oral Presentation, WPCCID, Singapore 2011

Clinical Practice Guidelines for the Diagnosis, Treatment and Prevention of Schistosomiasis japonicum infections in the Philippines: 2010 Update. Convenor and Chair, Technical Working Group – for Department of Health National Schistosomiasis Control Program – WPRO MVMM

Philippine Guidelines for H1N1, 2009, Member Technical Working Group

Consultant, Policy paper:  Developing an integrated policy framework for avian influenza preparedness, 2009 (UPEcon-HPDP project for USAID)

Consultant, Policy paper:  Refining strategies for the control of TB in the private sector, 2007 (UPEcon-HPDP project for USAID)

Principal investigator, Prevalence and clinical determinants of community-acquired Legionella pneumonia at the Philippine General Hospital, thesis submitted and defended for MSc Clinical Epidemiology, 2005

Co-investigator, A rapid situation analysis of health policy and systems research in the Western Pacific Region. Completed 2005

Project Leader, Situation Analysis of PPM-TB DOTS Clinics in the Philippines; 2003 –2004 (PhilTIPS-USAID project)

Consultant, Private Provider Baseline Study on KAP in TB (PhilTIPS-USAID project), 2004

Consultant Facilitator, Building a Collaborative Quality Improvement Model to Implement Hospital Infection Control Programs; 2002-2003; Rational Pharmaceutical Management Plus – USAID

Ongoing Projects

Training of Trainors for the Roll out of the Updated Clinical Practice Guidelines on the Management of Schistosomiasis japonicum in the Philippines – July 2013 to present, in collaboration with the Department of Health National Schistosomiasis Control and Elimination Program

Economic evaluation of HPV, PCV and rotavirus vaccination – Jan 2014 to present

Therapeutic and prophylactic interventions for Schistosomiasis japonicum infections, a Cochrane systematic review and meta-analysis – 2012 to present

Updating of Philippine Guidelines on TB Diagnosis, Treatment and Prevention - 2014

Development of Philippine Clinical Practice Guidelines on Typhoid Fever – 2013 to present

Development of Philippine Clinical Practice Guidelines on Opportunistic Infections among Patients with HIV – 2013 to present

Resource person (lecturer and facilitator, coordinator) for research methodology workshops,  evidence-based medicine workshops, systematic review workshopsscientific paper writing workshop, clinical practice guideline development workshops for various professional medical societies, training programs of residents and fellows in various institutions

Serves as Thesis Adviser/Thesis Panel Member/Thesis Chair for MSc Clinical Epidemiology students of the Department of Clinical Epidemiology UP College of Medicine