Institute of Child Health and Human Development (ICHHD) Director

Anna Lena Lopez, MD, MPH

Director, Institute of Child Health and Human Development (ICHHD)

Contact number: +63-2-254-5205; +63-2-514-7707

Other Positions Held: 

Director
Institute of Child Health and Human Development
University of the Philippines Manila – National Institutes of Health
January 2015 to present

Research Associate Professor
Institute of Child Health and Human Development
University of the Philippines Manila – National Institutes of Health
July 2012 to present

Clinical Associate Professor (cross- appointment)
Department of Pediatrics
University of the Philippines Manila College of Medicine
July 2012 to present

Regional Director, Scientific Affairs, Asia-Pacific Region
Pfizer Inc.
May 2010- Oct 28, 2011

Senior Scientist
International Vaccine Institute
March 2008- April 2010

Scientist
International Vaccine Institute
March 2005 – February 2008
Cholera Vaccine Program Coordinator.
Kolkata site coordinator.
Member, IVI, Institutional Review Board. 2006-2010

Attending and Clinical Assistant Professor
Department of Pediatrics
New York Methodist Hospital, Weil-Cornell College of Medicine
January 2004- February 2005

Attending, Clinical Associate Professor
Department of Pediatrics
Division of Infectious Disease
University of the Philippines – Philippine General Hospital (PGH), Philippines
September 1996- August 2003

Degrees: 

Dr Lopez received her Bachelor’s degree and Doctor of Medicine from the University of the Philippines. She had her residency training in Pediatrics at the Albert Einstein College of Medicine, New York, USA and fellowship in Pediatric Infectious Diseases at Children’s Hospital Los Angeles and University of California Los Angeles Center for Health Sciences, Los Angeles, California, USA. She obtained her Masters in Public Health with Certificate in Vaccine Science and Policy from the Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Board Certifications:
American Board of Pediatrics, Sub-board of Pediatric Infectious
Diseases, August 1999, 2008
American Board of Pediatrics, October 1994, Re-certification November 2001
Philippine Pediatric Society, March 1997
New York State Medical Licensure, December 2003
Maryland Physicians Licensure, December 2002
California Medical Licensure, July 1994
U.S. Federal Licensure Examination, December 1992
U.S. Foreign Medical Graduates Examination for the Medical
Sciences, July 1990
Philippines Physicians Licensure Examination, August 1990 (Licensure active until present)

Recent Publications: 

Number of publications: >30

Lopez AL, Macasaet LY, Ylade M, Tayag EA, Ali M. Epidemiology of cholera in the Philippines. PLoS Negl Tropical Dis 2015;9:e3440 DOI: 10.1371/journal.pntd.0003440
Martin S, Lopez AL, Bellos A, Deen J, Ali M, Alberti K, et al. Post-licensure deployment of oral cholera vaccines: a systematic review. Bull World Health Organ 2014;92:881–893: doi: http://dx.doi.org/10.2471/BLT.14.139949

Anh DD, Lopez AL, Tran HT, Cuong NV, Thiem VD, et al. (2014) Oral cholera vaccine development and use in Vietnam. PLoS Med 11: e1001712.

Lopez AL, Gonzales MLA, Aldaba JG, Nair, GB. Killed oral cholera vaccines: history, development and implementation challenges. Ther Adv Vaccines 1-14. Online first 9 June 2014 DOI: 10.1177/2051013614537819

Kanungo S, Lopez AL, Ali M, Manna B, Kim DR, et al. (2014) Vibriocidal Antibody Responses to a Bivalent Killed Whole-Cell Oral Cholera Vaccine in a Phase III Trial in Kolkata, India. PLoS ONE 9(5): e96499. doi:10.1371/journal.pone.0096499

Kar SK, Sah B, Patnaik B, Kim YH, Kerketta AS, Shin S, Rath SB, Ali M, Mogasale V, Khuntia HK, Bhattachan A, You YA, Puri MK, Lopez AL, Maskery B, Nair GB, Clemens JD, Wierzba TF. (2014) Mass Vaccination with a New, Less Expensive Oral Cholera Vaccine Using Public Health Infrastructure in India: The Odisha Model. PLoS Negl Trop Dis 8(2): e2629. doi:10.1371/journal.pntd.0002629

Bhattacharya SK, Sur D, Ali M, Kanungo S, You YA, Manna B, Sah B, Niyogi SK, Park JK, Sarkar BL, Puri MK, Kim DR, Deen JL, Holmgren J, Carbis R, Dhingra MS, Donner A, Nair GB, Lopez AL, Wierzba TF, Clemens JD. 5 year efficacy of a bivalent killed whole-cell oral cholera vaccine in Kolkata, India: a cluster-randomised, double-blind,
placebo-controlled trial. Lancet Infect Dis. 2013 Dec;13(12):1050-6. doi: 10.1016/S1473-3099(13)70273-1.

Mogasale VM, Levin A, Maskery B, DeRoeck D, Kim YE, Clemens J, Lopez AL, Burgess C, Wierzba T. Oral cholera vaccines to control endemic disease: an economic and epidemiological modelling analysis. Lancet 2013 Oct; 382

You YA, Ali M, Kanungo S, Sah B, Manna B, Puri M, Nair GB, Bhattacharya SK, Convertino M, Deen JL, Lopez AL, Wierzba TF, Clemens J, Sur D. Risk Map of Cholera Infection for Vaccine Deployment: The Eastern Kolkata Case. PLoS ONE 2013;8(8):
e71173. doi:10.1371/journal.pone.0071173

Lopez AL, DeRoeck D, Maskery B, Levin A, Bultman J, Kim YE, Mogasale V. Country investment case study on cholera vaccination: Bangladesh. International Vaccine Institute. Seoul. 2013 February. Available from: http://www.ivi.int/web/www/04_03

Ali M, Sur D, You YA, Kanungo S, Sah B, Manna B, Puri M, Wierzba TF, Donner A, Nair GB, Bhattacharya SK, Dhingra MS, Deen JL, Lopez AL, Clemens J. Herd protection by a bivalent killed whole-cell oral cholera vaccine in the slums of Kolkata, India. Clin Infect Dis. 2013 Apr;56(8):1123-31

Khatib AM, Ali M, von Seidlein L, Kim DR, Hashim R, Reyburn R, Ley B, Thriemer K, Enwere G, Hutubessy R, Aguado MT, Kieny M-P, Lopez AL, Wierzba TF, Ali SM, et al. Effectiveness of an oral cholera vaccine in Zanzibar: findings from a mass vaccination campaign and observational cohort study. Lancet Infect Dis. 2012 Nov;12(11):837-44. doi: 10.1016/S1473-3099(12)70196-2. Epub 2012 Sep 4.

Hashim R, Khatib AM, Enwere G, Park JK, Reyburn R, Ali M, Chang NY, Kim DR, Ley B, Thriemer K, Lopez AL, Clemens JD, Deen JD, et al. (2012) Safety of the Recombinant Cholera Toxin B Subunit, Killed Whole-Cell (rBS-WC) Oral Cholera Vaccine in Pregnancy. PLoS Negl Trop Dis. 2012;6(7):e1743. doi: 10.1371/journal.pntd.0001743. Epub 2012 Jul 24.

Ali M, Lopez AL, You YA, Kim YE, Sah B, Maskery B, Clemens JD. Global Burden of Cholera. Bull World Health Organ 2012;90:209–218A. |doi:10.2471/BLT.11.093427

Levin A, Maskery B, DeRoeck D, Kim YE, Clemens JD, Lopez AL, et al. An Investment Case for the Accelerated Introduction of Oral Cholera Vaccines. International Vaccine Institute. Seoul. 2012 Available from: http://www.ivi.int/html/themes/www/download/IVI_Global_cholera_case.pdf

Chen Y, Deng W, Wang S-M, Mo Q-M, Jia H, Wang Q, Li S-G, Li X, Yao B-D, Liu C-J, Zhan Y-Q, Ji C, Lopez AL, Wang X-Y. (2011) Burden of Pneumonia and Meningitis Caused by Streptococcus pneumoniae in China among Children under 5 Years of Age: A Systematic Literature Review. PLoS ONE 6(11): e27333. doi:10.1371/journal.pone.0027333.

Sur D, Kanungo S, Sah B, Manna B, Ali M, Paisley AM, Niyogi SK, Park JK, Sarkar B, Puri MK, Kim DR, Deen JL, Holmgren J, Carbis R, Rao R, Nguyen TV, Han SH, Attridge S, Donner A, Ganguly NK, Bhattacharya SK, Nair GB, Clemens JD, Lopez AL. Efficacy of a Low-Cost, Inactivated Whole-Cell Oral Cholera Vaccine: Results from 3 Years of Follow-Up of a Randomized, Controlled Trial. PLoS Negl Trop Dis. 2011 Oct;5(10):e1289. Epub 2011 Oct 18.Doi:10.1371/ journal. Pntd.0001289

Lopez, AL. Cholera. In: Kliegman R, Stanton B, St. Geme, et al. Nelson’s Textbook of Pediatrics. 19th ed. Elsevier Saunders 2011.

Bhattacharya K, Kanungo S, Sur D, Lal Sarkar B, Manna B, Lopez AL, Bhattacharya M, Nandy S, Kumar Niyogi S. Tetracycline-resistant Vibrio cholerae O1, Kolkata, India. Emerg Infect Dis. 2011 Mar;17(3):568-9.

Anh DD, Lopez AL, Thiem VD, Grahek SL, Duong TN, Park JK, Kwon HJ, Favorov M, Hien NT, Clemens JD. Use of oral cholera vaccines in an outbreak in Vietnam: a case control study. PloS Negl Trop Dis. 2011 Jan 25;5(1):e1006.

Reyburn R, Deen JL, Grais RF, Bhattacharya SK, Sur D, Lopez AL, Jiddawi MS, Clemens JD, von Seidlein L. The case for reactive mass oral cholera vaccinations. PloS Negl Trop Dis. 2011 Jan 25;5(1):e952.

Ali M, Sur D, Lopez AL, Kanungo S, Ochiai RL, Manna B, Kim DR, Deen J, Bhattacharya SK, Clemens JD. Community participation in two vaccination trials in slums of Kolkata, India: a multi-level analysis. J Health Popul Nutr. 2010 Oct;28(5):450-7.

Kanungo S, Tsuzuki A, Deen JL, Lopez AL, Rajendran K, Manna B, Sur D, Kim DR, Gupta VK, Ochiai RL, Ali M, von Seidlein L, Bhattacharya SK, and Clemens JD. Use of verbal autopsy to determine mortality patterns in an urban slum in Kolkata, India. Bull World Health Organ. 2010 Sep 1;88(9):667-74.

Ali M, Deen JL, Khatib A, Enwere G, von Seidlein L, Reyburn R, Ali SM, Chang NY, Perroud V, Marodon F, Saleh AA, Hashim R, Lopez AL, Beard J, Ley BN, Thriemer K, Puri MK, Sah B, Jiddawi MS, Clemens JD. Paperless registration during survey enumerations and large oral cholera mass vaccination in Zanzibar, the United Republic of Tanzania. Bull World Health Organ. 2010 Jul 1;88(7):556-9

Kanungo S, Sah BK, Lopez AL, Sung JS, Paisley AM, Sur D, Clemens JD, Nair GB. Cholera in India: an analysis of reports, 1997-2006. Bull World Health Organ. 2010 Mar;88(3):185-91.

Sur D, Nair GB, Lopez AL, Clemens JD, Katoch VM, Ganguly NK. Oral cholera vaccines–a call for action. Indian J Med Res. 2010 Jan;131:1-3.

Lee JH, Choi SY, Jeon YS, Lee HR, Kim EJ, Nguyen BM, Hien NT, Ansaruzzaman M, Islam MS, Bhuiyan NA, Niyogi SK, Sarkar BL, Nair GB, Kim DS, Lopez AL, Czerkinsky C, Clemens JD, Chun J, Kim DW. Classification of hybrid and altered Vibrio cholerae strains by CTX prophage and RS1 element structure. J Microbiol. 2009 Dec;47(6):783-8.

Sur D, Lopez AL, Kanungo S, Paisley AM, Manna B, Ali M, Niyogi SK, et al. Efficacy and safety of a modified-killed- whole- cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trial. Lancet 2009;374:1694-1702.

Kanungo S, Paisley A, Lopez AL, Bhattacharya M, Manna B, Han SH, et al. Immune responses following one and two doses of the bivalent, killed, whole-cell, oral cholera vaccine among adults and children in Kolkata India: A randomized, placebo-controlled trial. Vaccine. 2009 Nov 16;27(49):6887-93.

Dutta S, Deen J, Sur D, Manna B, Kanungo S, Badhuri B, Lopez AL, von Seidlein L, Clemens JD, Bhattacharya S. Increased utilization of treatment facilities during a dengue fever outbreak in Kolkata, India. Dengue Bulletin. 2008;32: 162-166.

Minh NB, Lee JH, Cuong NT, Choi SY, Hien NT, Anh DD, Lee HR, Ansaruzzaman M, Endtz HP, Chun J, Lopez AL, Czerkinsky C, Clemens JD, Kim DW. Cholera outbreaks caused by an altered Vibrio cholerae O1 El Tor biotype strain producing classical type cholera toxin B in Vietnam 2007 – 2008. J Clin Microbiol. 2009 Mar 18.

DeRoeck D, Lopez AL, Carbis R, Clemens JD. The IVI’s innovative approach to closing the gap between vaccines for industrialized and developing countries. Global Forum Update on Research for Health Volume 5: 138-142.

Mahalanabis D, Lopez AL, Sur D, Deen J, Manna B, von Seidlein L, Carbis R, Han SH, Shin SH, Attridge S, Rao R, Holmgren J, Clemens J, Bhattacharya SK. A Randomized, Placebo- Controlled Trial of the Bivalent Killed, Whole-Cell, Oral Cholera Vaccine in Adults and Children in a Cholera Endemic Area in Kolkata, India. PloS ONE. 2008 Jun 4;3(6):e2323

Lopez AL, Clemens JD, Deen JL, Jodar L. Cholera vaccines for the developing world. Human Vaccines. 4:1 165-169; March/April 2008

Deen JL, von Seidlein L, Sur D, Agtini M, Lucas ME, Lopez AL, Kim DR, Ali M, Clemens JD. The high burden of cholera in children: comparison of incidence from endemic areas in Asia and Africa. PloS Negl Trop Dis. 2008 Feb 20;2(2):e173.

Ali M, Emch M, Yunus M, Sack D, Lopez AL, Holmgren J, Clemens J. Vaccine Protection of Bangladeshi infants and young children against cholera: implications for vaccine deployment and person-to-person transmission. Pediatr Infect Dis J. 2008 Jan;27(1):33-7

Dang Duc Anh, Do Gia Canh, Anna Lena Lopez, Vu Dinh Thiem, Phan Thi Long, Nguyen Hong Son , Jacqueline Deen, Lorenz von Seidlein, Rodney Carbis, Seung Hyun Han, Seong Hye Shin, Stephen Attridge, Jan Holmgren, John Clemens. Safety and immunogenicity of a reformulated Vietnamese bivalent killed, whole-cell, oral cholera vaccine in adults. Vaccine 2007:25;1149-1155.

Bianconi S, Gudavalli M, Sutija VG, Lopez, AL, Barillas-Arias L, Ron N. Ranitidine and late-onset sepsis in the neonatal intensive care unit. J Perinat Med. 2007;35(2):147-50.

SonLa Study Group. Using a fingerprint recognition system in a vaccine trial to avoid misclassification. Bull World Health Organ 2007 Jan;85(1):64-7

Lopez, AL. Specimen Collection and Handling. In: Caballes AB, Sablan BP, eds. Handbook of Pediatric Bedside Procedures. Manila. University of the Philippines Manila Press; 2000: 163-172.

Bravo LC, Gatchalian SR, Gonzales MM, Lopez AL et al. Handbook of Pediatric Infectious Diseases (An Easy Guide). University of the Philippines Manila Press, Manila. 2002.

Lopez, AL, Pineda EF, Gerakian A, Cherry JD. Effect of Heat Inactivation of Serum on Bordetella pertussis Antibody Determination by ELISA. Diagn Microbiol Infect Dis 1998; 30 (1): 21-24

Lopez AL, Blumberg DA. An Overview of the Status of Acellular Pertussis Vaccines in Practice. Drugs 1997; 54 (2) 189-196

Tigno XT, et al Depressant Effects of Vitek negundo on Cardiac Function Acta Medica Philippines 1986: 22-159.