Nevado, Jose B. Jr

Institute of Human Genetics
Email Address:
Research Areas: 
Molecular Biology
Internal Medicine
Translational Medicine
My research advocacy can be summarized into a few distinct agenda. First, I want to focus on topics that are of immense clinical and public health relevance, that is, the most common medical conditions of our community. These will include infectious diseases, cardiovascular diseases, cancer and diabetes. Second, I want to promote the elucidation of mechanisms of diseases using relevant and modern technology. Through these methods, I intend to discover therapeutic targets, diagnostic markers and prognostic indicators that could be eventually useful for healthcare applications. Nevertheless, I am also aware that cost-effective strategies are warranted, especially in the setting of a developing nation like the Philippines. Third, I advocate translational approach in biomedical research discovery. I intend to use animal models following good laboratory practices, and to proceed to clinical studies once safety is well established and a high likelihood of useful application is presumed.
Relevant Publications: 
  1. Cooley BC, Nevado J, Mellad J, Yang D, St Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC, Boehm M. TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med. 2014 Mar 12;6(227):227ra34. (MAIN AUTHOR; ISI journal; IMPACT FACTOR: 15.843 )
  2. Nevado JB, Imasa MS. Homocysteine predicts adverse clinical outcomes in non-ST elevation acute coronary syndromes. Coron Artery Dis. 2008 May;19(3):153-61. (MAIN AUTHOR; ISI journal; IMPACT FACTOR: 1.254)
  3. Imasa MS, Gomez NT, Nevado JB. Folate intervention in non-ST coronary syndromes. Asian Cardiovasc Thorac Ann. 2009 Jan;17(1):13-21.  (Peer-reviewed; Under Web of Science; CORRESPONDING AUTHOR)
  4. Nevado JB, Imasa MS. Homocysteine and clinical profile of Filipino survivors of non-ST myocardial infarction and unstable angina. Implications from the FINEST study. PJIM Aug, 2007 45: 179-184.  (MAIN AUTHOR)
  5. PH2013000059. YU, Grace B.; BITENG, Eunice V.; LEAÑO, Milagros B.; CAOILI, Salvador C.; NEVADO, Jose Jr. B.; ESTACIO, Rhodora C. Diagnosis and detection of dengue virus infection using chicken egg antibodies. Feb 15 2013 (CO-INVENTOR;  Patent application)